Wednesday, October 9, 2013

School roundup: Lions golf clinches C&I title

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OSTERVILLE ? Brian O'Donnell and Justin Smith swept their No. 1 and 2 matches, leading Pope John Paul II golf over Sturgis East, 38?-15?, to clinch the Cape & Islands League title at Wianno Club on Tuesday.

O'Donnell was the medalist on the day as the Lions improved to 11-4-1, 9-1 in the league, winning the C&I for the first time.

The Lions also got wins from Blake Waters, Seamus McArdle and Blake Detterman.

GIRLS VOLLEYBALL

Pope John Paul II 3, Sturgis West 2: The Lions used a strong passing game to outlast the Navigators in Cape & Islands League play at the Hyannis Youth & Community Center.

Pope John Paul II (7-9, 4-1 C&I) survived Sturgis West (6-3, 3-2 C&I) 25-22, 25-14, 24-26, 21-25, 15-11 on the strength of Maria Mazzola's 21 assists and Kate Conway's 18 assists.

Corey Lopes had 17 digs for the Lions while Brianne Kondratowicz added eight digs.

Emily Langdon led the Navigators from a five-point deficit to a two-point lead with a seven-point service run in the Game 3 win. Langdon had three aces on the match.

Maryssa McKoul (seven blocks) and Becca Rowe (seven kills) keyed Sturgis West's Game 4 victory with strong play up front.

Sturgis East 3, Cape Tech 0: The Storm got an all-around team effort in moving above the .500 mark with the three-game sweep in Harwich.

Sturgis East (6-5, 3-2 C&I) prevailed 25-15, 25-7 and 25-8 with Haley Meaden's ace wrapping it up.

Laura Sirhal and Cat Cameron excelled from the service line for the Storm while Hannah Newcomb and Gwen Walsh starred defensively.

South Shore Voke 3, Upper Cape 0: The Rams played the Vikings tough, but came up just a few points short in all three games in Hanover.

South Shore Voke won 25-20, 25-20 and 25-22 over Upper Cape (3-9).

Rebecca Wolf (seven assists) and Sabrina Carboneau (two tips) combined for 17 service points. Gina-Marie Baxter added 17 of her own service points and three digs.

FIELD HOCKEY

Barnstable 1, Nantucket 1: Both teams had their chances but the hard-fought match ended in a tie on Nantucket.

The Red Raiders dominated the first half and the Whalers came out hot in the second half.

The Whalers finally punched through in the 21st minute, but Barnstable responded when Callie Rogorzenski scored off a corner from Amanda Piknick.

Barnstable (7-4-2) will travel to Dennis-Yarmouth on Friday.


Source: http://www.capecodonline.com/apps/pbcs.dll/article?AID=/20131009/SPORTS/310090306/-1/rss06

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How mobile changed bricks-and-mortar shopping ? for better or worse

Scott Forshay is senior strategist at Mutual Mobile

Scott Forshay is senior strategist at Mutual Mobile

By Scott Forshay

Remember approximately ten years ago when consumers would go on the hunt for a particular electronic device or appliance? Rather than spending hours traveling from store to store, comparing prices and product specs, they would oftentimes settle for a well-known brand purchased through a store they trusted.

Thanks to today?s mobile-heavy environment, that traditional idea of the consumer shopping experience is as good as gone.

Show grooming
A 2013 report by Pew Research shows that 56 percent of U.S. consumers own a smartphone, giving them instant access to the Internet and every product that can be found online.

With that kind of accessibility to pricing, product specs and customer reviews, mobile devices have created the showrooming effect ? a phenomenon where bricks-and-mortar stores become glorified showrooms for huge online retailers such as Amazon, providing a place for consumers to look at a potential purchase before buying it elsewhere for less.

Mobile has turned products into commodities and online incentives such as home delivery and next-day shipping have taken away any incentive for a consumer to purchase a product in-store, creating an environment where shopping is no longer about the store loyalty, or the in-store experience, but about price, convenience and customer benefit.

However, this shift towards online retail does not spell the end of traditional bricks-and-mortar commerce.

If anything, mobile?s immersion in our everyday lives actually provides retailers a valuable opportunity to embrace mobile as an asset and use it to foster the biggest advantage a bricks-and-mortar store has to offer: personalized, superior-level customer service.

Talking shop
With the explosion of mobile, retailers have been forced to rethink how they do business at a store level, and effectively compete with online retailers.

Through this process, many bricks-and-mortar shops have returned to their roots, cultivating an environment of exceptional customer service and providing a greater degree of efficiency to customers? lives, which in turn tilts the customers? ?What?s in it for me? scenario in favor of in-store retailers.

These retailers can also use mobile to their advantage. Here are three ways are bringing success to bricks-and-mortar locations:

? Social retailing. Some stores have found ways to make in-store shopping a more social experience and connect it to a consumer?s digital world.

Macy?s is a fantastic example of this. As a way to connect with its digital-savvy customers, Macy?s developed a ?Magic Fitting Room? that made it possible for in-store customers to virtually try on the latest styles on Macy?s Hot List and share their favorite looks to their social channels instantly.

In just six weeks, Macy?s saw more customers in-store, with more than 16,000 customers participating in this social retailing experience

? In-store pickup. One way to provide efficiency and utility to a consumer?s life is by allowing her to make purchases online while at the office or running errands and pick-up in store. This is something Walmart has been doing for a long time, and with immense success.

? Just-in-time advertising. Once a customer enters the store, whether to showroom or shop, mobile gives retailers a way to keep her there.

Through CRM tools, retailers have the ability to recognize customers with an affinity for their brand ? perhaps they have downloaded your mobile application ? and use targeted special offers to drive positive purchase intent in the store.

WHAT IT BOILS down to is what your bricks-and-mortar store can offer a potential customer that an online retailer cannot, and how you can use the existing tools that customers have at hand to your store?s advantage.

My advice: make mobile your friend rather than your enemy.

Embrace the changing shopping model and mold it to your benefit, but never forget to maintain strong customer relationships through service and personalization.

Through this, you may just find your customers embracing a loyalty to your brand that mobile almost made them forget.

Scott Forshay is senior strategist at Mutual Mobile, Austin, TX. Reach him at scott.forshay@mutualmobile.com.



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Tags: bricks and mortar, customer service, luxury, luxury marketing, mobile, mobile advertising, mobile commerce, mobile marketing, Mutual Mobile, retail stores, Scott Forshay, showrooming

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Source: http://www.mobilecommercedaily.com/how-mobile-changed-bricks-and-mortar-shopping-%E2%80%93-for-better-or-worse

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T-Mobile Takes Aim At Rival Carriers With Free, Unlimited International Data

tmobileT-Mobile USA just loves to crow about how different it is from the rest of its carrier rivals, it decided to show off the latest of its "Uncarrier" moves at a packed concert/press event in New York City's Bryant Park. Here's the gist of it: if you're a T-Mobile customer on one of their Simple Choice plans, you can now use unlimited data in 100+ countries totally free of charge.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/7JCrCCZxctA/

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Tuesday, October 8, 2013

Vickie Guerrero Passes College Entrance Exams http://bit.ly/17P6YMW #wwe #tna

Sorry, Readability was unable to parse this page for content.

Source: http://www.facebook.com/WrestlingNewsSource/posts/542693192465838

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New funding for Camplyobacter coli research

New funding for Camplyobacter coli research [ Back to EurekAlert! ] Public release date: 8-Oct-2013
[ | E-mail | Share Share ]

Contact: Andrew Chapple
andrew.chapple@ifr.ac.uk
01-603-251-490
Norwich BioScience Institutes

Campylobacter bacteria are a leading cause of food poisoning in the UK, causing at least 500,000 infections each year. Although these cases are rarely fatal, there's a clear need to reduce illness and its associated costs caused by these bacteria.

The major source of infection is through eating undercooked poultry meat, but other sources, such as farm animals and water also contribute to the large number of infections. A concerted effort is underway to tackle the problem, from farm to the plate. Organisations including the Food Standards Agency, Defra and the Biotechnology and Biological Sciences Research Council are co-funding research to better understand how Campylobacter infects chickens, and how it persists in the food chain.

Much of this research is focused on a better understanding of the bacteria and how they survive in different environments. One complication is that Campylobacter illness is caused by at least 20 different species of Campylobacter bacteria. Whilst the vast majority of infections are down to one well studied species, Campylobacter jejuni, an estimated 10% of cases are caused by a different species, Campylobacter coli. Much less is known about the biology of Campylobacter coli including where it resides in the environment and how it infects us.

To address this, the Food Standards Agency has given a Strategic Research grant to a consortium led by Dr Arnoud van Vliet of the Institute of Food Research, to develop new tools to understand Campylobacter coli at the molecular and genetic level. In collaboration with The Genome Analysis Centre (TGAC) and the University of East Anglia, partners with IFR on the Norwich Research Park, and scientists at the University of Swansea, University of Liverpool and Public Health England, the researchers will carry out next generation genome sequencing of 500 genomes from Campylobacter coli strains. These strains will be collected from a wide range of sources including animals, foods, humans and a range of different environments.

When these genomes are analysed and compared, it should be possible to pick out genetic markers that identify strains from particular environmental niches, and possibly even predict why these strains prefer a particular environment.

These markers and other information that can be obtained from the first in depth look at the genome of C. coli will be invaluable tools for researchers studying these bacteria. They will help answer questions about what the main sources of C. coli infection are. Some research suggests that game, tripe and recreational swimming may be significant sources of infection a major difference to Campylobacter jejuni. The knowledge obtained from this two-year study could be used to develop diagnostic tools to help confirm diagnose and track sources of C. coli contamination a tool we don't currently have.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New funding for Camplyobacter coli research [ Back to EurekAlert! ] Public release date: 8-Oct-2013
[ | E-mail | Share Share ]

Contact: Andrew Chapple
andrew.chapple@ifr.ac.uk
01-603-251-490
Norwich BioScience Institutes

Campylobacter bacteria are a leading cause of food poisoning in the UK, causing at least 500,000 infections each year. Although these cases are rarely fatal, there's a clear need to reduce illness and its associated costs caused by these bacteria.

The major source of infection is through eating undercooked poultry meat, but other sources, such as farm animals and water also contribute to the large number of infections. A concerted effort is underway to tackle the problem, from farm to the plate. Organisations including the Food Standards Agency, Defra and the Biotechnology and Biological Sciences Research Council are co-funding research to better understand how Campylobacter infects chickens, and how it persists in the food chain.

Much of this research is focused on a better understanding of the bacteria and how they survive in different environments. One complication is that Campylobacter illness is caused by at least 20 different species of Campylobacter bacteria. Whilst the vast majority of infections are down to one well studied species, Campylobacter jejuni, an estimated 10% of cases are caused by a different species, Campylobacter coli. Much less is known about the biology of Campylobacter coli including where it resides in the environment and how it infects us.

To address this, the Food Standards Agency has given a Strategic Research grant to a consortium led by Dr Arnoud van Vliet of the Institute of Food Research, to develop new tools to understand Campylobacter coli at the molecular and genetic level. In collaboration with The Genome Analysis Centre (TGAC) and the University of East Anglia, partners with IFR on the Norwich Research Park, and scientists at the University of Swansea, University of Liverpool and Public Health England, the researchers will carry out next generation genome sequencing of 500 genomes from Campylobacter coli strains. These strains will be collected from a wide range of sources including animals, foods, humans and a range of different environments.

When these genomes are analysed and compared, it should be possible to pick out genetic markers that identify strains from particular environmental niches, and possibly even predict why these strains prefer a particular environment.

These markers and other information that can be obtained from the first in depth look at the genome of C. coli will be invaluable tools for researchers studying these bacteria. They will help answer questions about what the main sources of C. coli infection are. Some research suggests that game, tripe and recreational swimming may be significant sources of infection a major difference to Campylobacter jejuni. The knowledge obtained from this two-year study could be used to develop diagnostic tools to help confirm diagnose and track sources of C. coli contamination a tool we don't currently have.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-10/nbi-nff100813.php

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US?s largest creditor China ?concerned about developments in US fiscal cliff?

A senior Chinese official has warned that the ?clock is ticking? to avoid a US default that could hurt China?s interests and the global economy.US-Congress-Capitol-Hill
China, the US?s largest creditor, is ?naturally concerned about developments in the US fiscal cliff?, Vice Finance Minister Zhu Guangyao said.

Washington must agree a deal to raise its borrowing limit by 17 October, or risk being unable to pay its bills.

He asked that ?the US earnestly take steps to resolve? the issue.

US Treasury Secretary Jacob Lew has said that unless Congress agrees an increase in the debt ceiling by 17 October, Washington will be left with about $30 billion (?18.6 billion) in cash to meet its obligations ? about half the $60 billion-a-day needed.

For many governments and investors the approaching deadlock over the debt ceiling is far more critical than the current impasse over the federal shutdown caused by Congress?s failure to agree a new budget.

On Sunday Republican House Speaker John Boehner reiterated that Republican lawmakers would not agree to raise the debt ceiling unless it included measures to rein in public spending.

Zhu said that China and the US are ?inseparable?. Beijing is a huge investor in US Treasury bonds.

?The executive branch of the US government has to take decisive and credible steps to avoid a default on its Treasury bonds,? he said.

?It is important for the US economy as well as the global economy.?

?We hope the United States fully understands the lessons of history,? Zhu said, referring to a similar deadlock in 2011 that led to a downgrade of the US ?AAA? credit rating.

That deadlock ended with an eleventh-hour agreement.

Source: http://inserbia.info/news/2013/10/uss-largest-creditor-china-concerned-about-developments-in-us-fiscal-cliff/

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Popular CBS app finally to launch on Android and Windows 8 devices

"Hawaii Five-0" is one of the more popular shows on CBS's new app, which is rolling out to Android and Windows devices.

Hey, Android and Windows phone users, CBS loves you too. Just not as much as iPhone users. CBS Interactive announced that it has finally rolled out its app on Android and Windows 8-connected devices. BlackBerry users, if you're still out there, you'll have to wait until Christmas.

CBS's app allows its users to watch every episode of new and continuing primetime shows eight days after the initial broadcast. Viewers can access daytime and late-night shows within 24 hours. Shows from CBS's vault are also available through the app, including "Star Trek" and "Perry Mason." CBS Interactive also uses the app to engage users with a second screen, allowing viewers to watch the show on their TV and use the app for behind-the-scenes info or games that tie into the programming.

Released in March, the app was only available on Apple's iOS but proved to be very popular. The app was downloaded 4 million times. CBS shows that have interested social viewers the most so far include ?Criminal Minds,? ?CSI: Crime Scene Investigation,? ?Hawaii Five-0,? ?NCIS: Los Angeles,? ?The Bold and the Beautiful,? ?Survivor? and ?The Mentalist."

Now that Nielsen is counting views up to three days after the initial broadcast, it's more important than ever that networks entice viewers to use apps to boost the networks' numbers. The more users watch via the apps, the better the networks' numbers will be for advertisers.

?When we launched on iOS, we promised fans we would bring the CBS App to all major platforms by fall premieres. Today we are doing exactly that,? Jim Lanzone, president of CBS Interactive, said in a statement. ?We've seen a tremendous response to the app to date, and we'll continue to innovate on behalf of CBS fans in the weeks and months ahead.?

Gina Hall is a Los Angeles-based writer and producer with more than 10 years experience in television, documentary and feature film production. She is a graduate of USC?s School of Cinematic Arts and blogs for the Huffington Post at huffingtonpost.com/gina-hall

Source: http://feedproxy.google.com/~r/vertical_46/~3/oKEWi30oIzw/popular-cbs-app-finally-to-launch-on.html

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Monday, October 7, 2013

Japan-only Samsung Galaxy J leaks with Snapdragon 800, 5-inch display

Typically, Samsung's smartphones for Japan aren't much more than slight modifications of its regular devices. The company may soon cater directly to local tastes, however: a leaked NTT DoCoMo brochure on 2ch.net has revealed the Galaxy J, which appears to be designed solely for the Land of the ...

Source: http://www.engadget.com/2013/10/07/samsung-galaxy-j-leaks/?ncid=rss_truncated

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Friday, October 4, 2013

Nokia Lumia 1020 and 625 arrive for Canada

nokia-lumia-1020-625-canada

Nokia has announced today that the Nokia Lumia 1020 and Lumia 625 smartphones have both now arrived for Canada. Potential buyers of a Windows Phone handset in Canada may have been waiting for these devices to appear there, and we have price details and more ahead.

The Lumia 1020 is a flagship device for the high-end of the market while the Lumia 625 is a more affordable smartphone, so these offer something to suit most requirements and budgets. We?ll start with the top-notch Lumia 1020 that is very much aimed at those that want an excellent smartphone camera experience.

Rogers and Telus are now both selling the Lumia 1020 at a price of $199 on the usual two-year contract. The phone is available in yellow or black and if you want to purchase it contract free it will cost between $600 and $725.

nokia-lumia-1020-625-canada-b

Key specs of the Lumia 1020 include a 1.5GHz dual-core processor, a 4.5-inch display with resolution of 1280 x 768, 2GB of RAM, and 32GB of internal storage (non-expandable). It also has a whopping 41-megapixel rear camera. The Lumia 1020 camera grip is also available in both color options with a price tag of $75.

The much cheaper Lumia 625 is available in black and is an exclusive with Telus. The handset is free with a contract or if you don?t want to be tied to a contract it will set you back $300. Key specs include a 1.2GHz dual-core processor, 4.7-inch display with resolution of 800 x 480, 512MB of RAM, 8GB of internal storage (expandable), and a 5-megapixel rear camera.

Both phones run Windows Phone 8, upgradable to WP8 Amber. Are you in Canada and pleased that these phones have finally released there? Are you considering purchasing the Nokia Lumia 1020 or the Nokia Lumia 625?

Source: Engadget

Source: http://www.phonesreview.co.uk/2013/10/03/nokia-lumia-1020-and-625-arrive-for-canada/

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Comelec to disqualify mayor for vote-buying

The Commission on Elections (Comelec) is set to disqualify another winner in the May 13 elections, this time a mayor, for alleged vote-buying.

Poll chief Sixto Brillantes Jr. did not name the mayor, but said a Comelec division has resolved to disqualify the proclaimed winner due to vote-buying.

"Para hindi kami masabihan na lagi kaming nagbibiro. Kapag may sinabi kaming isang bagay, tinutuloy namin," Brillantes said Wednesday.

The Comelec would issue a resolution on it in the next few days, he added.

The new disqualification case came after the Comelec First Division disqualified Laguna governor ER Ejercito for allegedly overspending in his 2013 elections campaign. Ejercito has filed a motion with the Comelec to reverse the decision.

Brillantes refused to give hints on the identity of the mayor, but noted that the Comelec had been alerted of the money, which is already in Comelec custody, after the elections.

A look at the Comelec website shows a statement that said the poll body took custody of some P692,000 slipped in envelopes that were place inside fruit juice boxes and were allegedly used for vote-buying.

The mayor was said to be from Bulacan province, according to the statement.

The Clerk of Court, which provides legal services to the Comelec in disqualification cases, among others, said this was the largest reported sum of money allegedly used for vote-buying.

Vote-buying, defined as giving or promising money or anything of value in exchange of a vote, is an election offense and may cause the disqualification of a candidate, and a one to six year imprisonment, according to the Omnibus Election Code. -- Marc Jayson Cayabyab/KBK, GMA News

Source: http://www.gmanetwork.com/news/story/329087/news/nation/comelec-to-disqualify-mayor-for-vote-buying

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Thursday, October 3, 2013

Dell Rejoins The Android Market With Two new Tablets

Dell Venue 8

?

?

It?s been a while since Dell and Android played together but the two have been now been reunited. ?Earlier today Dell announced a collection of new devices, two of which are tablets that will be running our favourite operating system, Android. ?There will be a 7? model known as the Venue 7 and and an 8? model known as, surprise surprise, the Venue 8.

One interesting thing about these devices is that they will feature Intel chipsets rather than the regular ARM chips. ?To be a bit more exact, the devices will feature 2GHz Intel Atom Clover Trail Plus chips as well as 2GB of RAM. ?Both will house 16GB of internal storage, microSD card slots, and IPS displays with a resolution of 1280?800. ?Both should also run for about 10 hours in between charges.

One minor difference between the two devices is the camera. ?The Venue 7 will feature a 3MP rear camera and VGA front facing camer while the Venue 8 has a slightly better 5MP rear camera and 2MP front shooter. ?One other minor variance is that the Venue 8 will come in 32GB as well. ?Both should get the LTE treatment down the road as well.

Software wise both will come with Android 4.2.2 out of the box which is pretty decent. ?Dell has said that they will work on bringing Android 4.4 KitKat as soon as possible but you know how updates go some times?When it comes to cost, both will be very reasonable with the Venue 7 costing just $150 and the Venue 8 costing $180.

Release date is slated for October 18 in the US and ?select countries.? ?No word on whether or not Canada will fit into ?select countries? but I?d say the chances are pretty high. ?Anybody interested?

[Dell / AndroidAuthority]

?

Source: http://feedproxy.google.com/~r/androidincanada/~3/rEtsAew1Qfs/

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Michael Grimm calls for a debt ceiling deal to end the shutdown

Rep. Michael Grimm said the moderate voices in the Republican Party have "two problems" in trying to negotiate an end to the current government shutdown, "one on the left, and one on the right."

"Within my own conference, everyone knows we have a far right faction," Grimm said on CNN's "New Day" this morning. But he also said Senate majority leader Harry Reid has been unwilling to listen to Republican overtures, and that President Obama hasn't effectively led on the issue.

Democrats have said flatly that they won't accede to any Republican demands to defund or delay the president's signature health care law, and Republicans have refused to pass a continuing resolution to fund the government that does not include such provisions.

"There's been a group of us from the beginning that said from day one, we don't want a shutdown," said Grimm who favored funding the government in the short-term, without the delay provisions, but also voted along party lines for the bills that caused the shutdown.

On CNN, Grimm proposed including the upcoming negotiations over the debt ceiling into the discussions.

"Why not deal with it right now?" he said. "Let's get everything done and finished so that there's some certainty in the markets and the American people aren't wondering are we going to go from a shutdown to failing on our credit."

Grimm said he was working with Rep. Peter King to build a moderate faction that could then approach leadership with some kind of a solution to end the shutdown. King told me yesterday the shutdown would do "lasting damage" to the Republican brand and could hurt members in marginal districts next year.

That list could include Grimm, whose Staten Island and Brooklyn district has historically flipped between the two parties. He's facing a challenge from Democratic councilman Dominic Recchia, who has issued a steady stream of press releases attacking Grimm for his role in the shutdown.

Source: http://www.capitalnewyork.com/article/politics/2013/10/8534228/michael-grimm-calls-debt-ceiling-deal-end-shutdown

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Def Leppard talks cancer, concert film, new music

Rocking with Def Leppard between bouts of chemotherapy proved healing for guitarist Vivian Campbell.

The 51-year-old musician relied on his bandmates and the thrill of performing to help him through a diagnosis of Hodgkins lymphoma (he started treatment in April). The band hit the road this summer for a monthlong tour that wrapped in July.

"We've actually been able to work through it," said Campbell. "We did the shows in Europe while I was doing chemo ... and mentally that was a big part of my recovery."

"I'm glad I had the opportunity to work through it instead of stay at home and feel sorry for myself," he added.

After more than 30 years together, Def Leppard isn't slowing down for cancer ? or anything else.

Fans can get a front-row seat to see the band at local cineplexes on Wednesday and again next week in "Def Leppard Viva! Hysteria Concert." Filmed during a Las Vegas residency earlier this year, it shows the quintet doing something unprecedented: performing the 1987 mega-hit album, "Hysteria," live from start to finish.

"It was fun, actually, and a totally different way of doing it," said guitarist Phil Collen. "It was a different dynamic doing the album in full, and it was much more theatrical."

Part of the theatrics came in the form of Ded Flatbird. Singer Joe Elliott suggested the band open for itself during its first-ever Vegas residency, but do it as a fake cover band.

"We would actually go out and pretend to be Ded Flatbird, who were supposedly the greatest Def Leppard cover band in the world," said Campbell. "Joe gave us all aliases. We became different characters, and as the shows progressed, we kind of developed those personalities a little bit more, and that was a fun part of the show...

"Then, of course, the curtain reveal and it's Def Leppard doing 'Hysteria.'"

Ded Flatbird performed nightly during the nine-show engagement, playing obscure material from the early days of Def Leppard and other tracks apart from the "Hysteria" album. Ded Flatbird's performances are included in the double CD and DVD set, "Viva! Hysteria," out on Oct. 22.

"We were so convincing that a lot of people didn't actually realize it was us," said drummer Rick Allen. "We actually got booed by a few people."

"Because we went out and found another one-armed drummer!" Campbell quipped. (Allen lost his left arm in a car accident a year after the release of the band's breakthrough album, 1983's "Pyromania.")

Next up for Def Leppard? New music.

The fivesome, which also includes bass player Rick Savage, plan to meet in Dublin in the new year to start writing.

"A whole Def Leppard album would probably take a bit long," Collen said. "So we're probably going to do an EP or something, get that out, then perhaps the year after, release an album."

---

Follow Sandy Cohen on Twitter: http://www.twitter.com/APSandy

---

Online:

http://www.defleppard.com/

http://www.fathomevents.com/#!def-leppard-viva-hysteria

Source: http://www.miamiherald.com/2013/10/02/3664852/def-leppard-talks-cancer-concert.html

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Wedding Sign, customized love song lyrics - " I cross my heart and promise to, give all I've got to give to make your dreams come true..." by AndTheSignSays

"I cross my heart and promise to, give all I've got to give to make your dreams come true .In all the wold you'll never find A Love as True as Mine"
Bride & Groom names
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If having a beach wedding, I could also add starfish to the bottom corners like in this sign below. Let me know that you'd like them in your check out message.
http://www.etsy.com/listing/91241004/beach-wedding-decoration-wedding-signs?ga_search_query=beach&ga_search_type=user_shop_ttt_id_6019300

I had a wonderful bride request this be made for her wedding and I absolutely love it! Now it's being offered to you! It would be beautiful displayed at a wedding, for a bridal shower gift, anniversary gift.

If you'd like your own wording, just convo me!

As pictured is vintage lightly distressed shabby style in vintage ivory and chcocolate lettering.
I can do another color combo, just let me know all colors in the check out message to seller section.

And take a peek at the rest of my romantic wedding signs here:
http://www.etsy.com/shop/AndTheSignSays?section_id=7689902

Measures approx 10x18
Sawtooth hanger
varnish

COPYRIGHT:
?2012 AndTheSignSays. Fellow artists, please refrain from copying my specifics designs. I thank you.

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Please be aware that I use pine wood which may have knots, small dinks, varied roughness and imperfections as to be expected of wood. I do sand each piece with an electric sander, but I do not attempt to completely cover these. I think they add warmth, charm & character to the sign. Each sign will vary depending on those characteristics, grain of the wood and distressing. For painted, shabby distressed signs, each will vary according to the distressing as well.

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PLEASE NOTE:

1...Please allow anywhere from 4 - 6 BUSINESS WEEKS for your sign to ship. Please convo me beforehand if needed before that period of time or if you need a rush.

2...Please always let me know you DATE NEEDED BY and/or WEDDING DATE in the message to seller section of the check out.

3...If you need to contact me, please do so through the Etsy convo system since I check that much more often than email.

Source: http://www.etsy.com/listing/97052810/wedding-sign-customized-love-song-lyrics

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Body Warm-up Stretches | Health and Fitness

Exercises?are a simple, effective way to improve?balance, flexibility, and strength. Going to gym may be time consuming and expensive, you can shape up your body while you are in bed room, however, if you can dedicate a small area for home gym, nothing is like it. Here are exercises that you can carry out and remain fit. Warm-ups are the key to unlocking tight muscles that may be a cause of injury. stretching is an important part of fitness: It can improve your range of motion, increase circulation, and calm your mind.

  • Neck Stretch. Neck Stretches

    Neck Stretches

  1. Sit or stand with shoulders relaxed with your back straight.
  2. Bring your left ear down toward your left shoulder and hold.
  3. Roll your head down toward the ground and bring your chin to your chest.
  4. Hold and finally, roll your head to the right and bring that ear to your right shoulder.
  5. Inhale and exhale in a slow and controlled manner.
  • Runner Stretch Runner Stretches

    Runner Stretches

  1. Step your right foot forward and lower into a lunge, placing your fingertips on the floor.
  2. Breathe in, then, in one motion, exhale as you straighten your right leg.
  3. Slowly return to the lunge position.
  4. Repeat same with left leg forward.
  • Standing Side Stretch? Standing Side Stretches

    Standing Side Stretches

  1. Stand with your feet together and your arms straight overhead.
  2. Clasp your hands together, with your fingers interlaced and pointer fingers extended.
  3. Inhale as you reach upward.
  4. Breathe out as you bend your upper body to the right.
  5. Take five slow breaths. Slowly return to the center.
  6. Repeat on the left side.
  • Leg Over Leg Over Stretches

    Leg Over Stretches

  1. Lie on your back, extending your left arm out to the side
  2. Take your left leg over your right, bringing the knee in line with the hips.
  3. Keeping your right leg straight, use your right arm to push down on the knee of the left leg, exhaling slowly as you stretch.
  • Quad Stretch Quad Stretches

    Quad Stretches

  1. Stand tall, holding on to a chair or wall for balance if necessary.
  2. Keep your feet hip-width apart, your back straight and your feet parallel.
  3. Reach back and grab your left foot in your left hand, keeping your thighs lined up next to each other and left leg in line with the hip.
  4. Repeat on opposite side.
  • Forward Hang Forward Hang Stretch

    Forward Hang Stretch

  1. Stand with your feet hip-distance apart and your knees slightly bent. Interlace your fingers behind your back.
  2. Breathe in and straighten your arms to expand your chest.
  3. Exhale and bend at your waist, letting your hands stretch toward your head.
  4. Hold for five deep breaths.
  • Triceps Stretch Triceps Stretches

    Triceps Stretches

  1. Stand tall or sit upright.
  2. Place your left elbow in your right hand. Reach your left arm overhead, placing palm on the center of your back and supporting the elbow in your right hand.
  3. Reach your fingertips down your spine. Keep the shoulders relaxed away from the ears.
  4. Move towards right
  5. Repeat with opposite arm and side.

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Source: http://healthinessbox.com/2013/10/02/body-warm-up-stretches/

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Sunday, September 29, 2013

This Vampiric Vacuum Vants to Suck Your Blood (and Save Your Life)

This Vampiric Vacuum Vants to Suck Your Blood (and Save Your Life)

Normally, when you suffer from a pulmonary embolism?a blood clot blocking the flow to your lungs or heart?you've only have two options; undergo chest-cracking open-heart surgery, or die. But thanks to an ingenious new blood filter system, doctors will be able to save lives without destroying sternums or requiring weeks of recovery.

Read more...


    






Source: http://feeds.gawker.com/~r/gizmodo/full/~3/KTM402wog_M/this-vampiric-vacuum-vants-to-suck-your-blood-and-save-1403011438

The Fosters

Saturday, September 28, 2013

End brinkmanship and pass spending bill, urges Obama

Washington (AFP) - As the US government careened toward a potentially devastating shutdown, President Barack Obama urged intransigent lawmakers to end their brinkmanship and pass a spending bill.

But with barely 72 hours before agencies are forced to close their doors Tuesday and more than a million US troops remain on duty without pay, Congress appeared no closer to resolution of a fiscal crisis that looms over Washington and the nation.

And Republicans driving the agenda in the House of Representatives, which will hold an emergency session Saturday to consider legislation to keep the government open, appeared to struggle over the way forward.

The president hailed the Senate for clearing a stopgap federal funding measure Friday that knocked the ball into the House's court, where a diehard conservative faction is bent on thwarting Obama's health care law.

The Republican-led lower chamber will likely tweak the bill and send it back to the Senate, which could leave insufficient time for the legislation to pass both chambers before a fiscal year-end deadline of midnight Monday.

"Over the next three days, House Republicans will have to decide whether to join the Senate and keep the government open or shut it down because they can't get their way," Obama said.

Republicans, overwhelmingly opposed to so-called Obamacare, inserted a provision in the House measure that strips funding for the health care law, but the Democratic-led Senate removed it and sent the bill back.

Some Republicans would now like to see the health care law fight shift to the next fiscal battle -- over the debt ceiling.

The Treasury says it will reach its $16.7 trillion borrowing cap by October 17, and if Congress does not raise it the country will default on its debts for the first time in history.

The president said a default "would have a profound destabilizing effect on the entire economy -- on the world economy."

"We've got to break this cycle," Obama added. "My message to Congress is this: do not shut down the government. Do not shut down the economy. Pass a budget on time. Pay our bills on time."

With the mere threat of a shutdown likely having "a dampening effect on the economy," Obama suggested it was time for House Speaker John Boehner to isolate the "extremists" who are holding the Republican Party captive.

But that had yet to happen. The leadership of the House was crafting a bill that would raise the debt limit, delay the health care law's implementation by one year, greenlight the controversial Keystone oil pipeline and lower taxes for the wealthy.

Obama said he is willing to negotiate on such issues, "but we're not going to do this under the threat of blowing up the entire economy."

"Nobody gets to threaten the full faith and credit of the United States just to extract political concessions," Obama said.

House leaders insist they do not want a shutdown or a default, but Senate Majority Leader Harry Reid said his chamber's bill was the only one that could prevent a shutdown.

"This is it. Time is gone," Reid said after the Senate voted along strict party lines to approve federal funding until November 15.

The Democrat also challenged Boehner to schedule a House vote on the stripped-down budget bill, saying it would pass "overwhelmingly if the speaker had the courage to bring it to the floor."

"I think they should think very carefully about their next step," Reid added.

Some Republicans have spoken out about their conservative colleagues' strategy, warning of a backlash should government shut down.

"If anybody creates a process where our military doesn't get paid, and their families, they're going to make an enemy ... of me for life," Senator Lindsey Graham fumed to Roll Call.

As the clock ticks down, Republicans stressed that Obama was merely commenting from the sidelines, not meeting with or even calling Boehner this week to thrash out a compromise.

"Grandstanding from the president, who refuses to even be a part of the process, won't bring Congress any closer to a resolution," Boehner spokesman Brendan Buck said.

With Congress and the White House feuding, the Pentagon announced worrying details of how a stoppage would effect the department.

It said the military's 1.4 million troops will remain on duty in the event of a shutdown, but not get paid until Congress appropriated funds to compensate them.

And if government agencies close, half the Defense Department's nearly 800,000 civilian workers would be ordered to stay home.

Source: http://news.yahoo.com/obama-statement-amid-fiscal-crisis-192241197.html

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Syria rebel chief: extremists 'stealing revolution'

Beirut (AFP) - The head of the key Syrian opposition National Coalition, Ahmad Jarba, has denounced extremists he said were trying to "steal our revolution", and blamed the regime for supporting them.

He made the comments in an address in New York to representatives from the Friends of Syria -- international backers of the rebels seeking to overthrow President Bashar al-Assad.

"The Syrian people support peace and moderation, tolerance and coexistence," Jarba said.

"The phenomenon of extremism appeared with the support and planning of the regime, which has gambled on the transformation of a revolution for freedom into a civil and sectarian war," he added.

The Syrian regime "created and armed numerous terrorist organisations and left them a place in the regions from which it has been removed," he said.

"Other groups have come across the borders to steal our revolution."

An unknown number of foreign fighters has streamed into Syria to join jihadist rebel groups such as the Al-Qaeda-affiliated Al-Nusra Front and Islamic State of Iraq and the Levant (ISIL).

They include fighters from Europe, the Middle East and Chechnya.

Rebels initially welcomed the jihadist groups and the foreign fighters who joined them, eager for weapons and battle experience.

But in recent months, relations have been tense, particularly between ISIL and non-jihadist rebel factions, which have clashed on occasion.

This week, some of the biggest non-jihadist battalions formed an alliance that includes Al-Nusra, and announced their rejection of the Coalition that Jarba heads.

He told the meeting, on the sidelines of the UN General Assembly, that extremism "has increased because of the indifference of the international community, which has failed in its duties to the Syrian people".

The opposition has repeatedly called on its international backers to provide it with weapons, but the West has been reluctant to do so for fear of the arms falling into the hands of groups such as Al-Nusra, which is listed as a "terrorist" organisation by much of the West.

Despite setbacks, Jarba insisted that the only solution to the conflict would be Assad's departure.

"There is no horizon for the Syrians before the fall of the regime," he said.

"When it goes, Syrians will regain their freedom and civil peace and harmony will be restored."

Source: http://news.yahoo.com/syria-rebel-chief-extremists-stealing-revolution-103752863.html

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VIDEO TNA can?t ask for withdrawal of troops from North ? President

  • Ada Derana - Saturday 28th September, 2013

    A woman was killed in a fire which broke out at a residence in Daluwawella, Puttalam this morning. Police said the fire had erupted at around 1.30am today and that residents in the area had discovered the ...

  • Mahinda Rajapaksa This is all propaganda

    General Sources - Saturday 28th September, 2013

    The report paints a grim picture of the country: The military is dominating Sri Lanka's life in many areas; critics of the government are abused, silenced or killed; and minorities such as Buddhists, Christians and Muslims are attacked, the report stated. All under the watch of President Mahinda Rajapaksa, who was elected in 2005 and re-elected by his people three years ago - a man who is ...

  • Verugal PS Chairman released on bail

    Ada Derana - Saturday 28th September, 2013

    The Chairman of the TNA controlled Verugal Pradeshiya Sabha, who was arrested in connection with a financial fraud, has been released on bail by the Muthur ...

  • Sri Lankan nationals in court over cash machine frauds

    Ada Derana - Saturday 28th September, 2013

    Four Sri Lankan men have appeared in court in connection with a series of cash machine scams around Gloucestershire, England.Basheer Mustafa Ebrahim, 21, and Ashok Balasubramanian, 22; Thanfavel Vilvanadham, 50, all of South End Road in Croydon, London; and Kusalakumar Sithambarapillai, 48, of Barnard Gardens in Hayes, Middlesex were arrested on the M25 in Surrey on Monday, September 23.The Sri ...

  • Tamil Nadu Andhra Pradesh sitting on bed of diamonds Report

    Times of India - Saturday 28th September, 2013

    Avast area in southeast India - 200,000 sq km - could contain diamond-bearing rocks, says a report published in the August issue of ...

  • Sri Lanka receives broad cross-regional support in HRC

    Ada Derana - Saturday 28th September, 2013

    Sri Lanka received strong cross-regional support in the Human Rights Council from countries in Asia, Africa and Latin America on Thursday ( 26 September 2013) which uniformly welcomed and commended the ...

  • Harper should help Tamils by going to Sri Lanka

    The Globe and Mail - Friday 27th September, 2013

    Chief Minister-elect for Sri Lanka's northern provincial government, retired Supreme Court Justice C.V. Wigneswaran flashes a victory sign following a media briefing in Jaffna, Sri Lanka, Sunday, Sept. 22, 2013. The Tamil National Alliance, a former political proxy for Sri Lanka's defeated Tamil Tiger rebels swept the country's northern provincial election, according to results ...

  • Report Sri Lanka becoming to pricey for visitors

    eTN - Friday 27th September, 2013

    COLOMBO, Sri Lanka - A study which gauges the value for money factor of tourist resorts, has seen the Indonesian island of Bali toppling Sri Lanka from the once held top spot as the 'best value' long-haul travel option in a new list of popular holiday destinations, the Daily Mail reported. The latest Post Office Travel Money Long Haul Report - which gauges the countries that offer the ...

  • Sri Lanka be on GUARD

    General Sources - Friday 27th September, 2013

    When countries are eyed to serve the self-interests of a handful of 'civilized' nations they know the perfect medicine to ensure these targeted nations are brought to their knees. The break-up of Yugoslavia serves as a catalyst for why Sri Lanka needs to be alert at all times. Yugoslav Federation comprised Bosnia and Herzegovina, Croatia, Macedonia, Montenegro, Serbia, Slovenia and ...

  • Bharatha Lakshman assassination case put off for October 11

    General Sources - Friday 27th September, 2013

    The case against Colombo district MP Duminda Silva and 10 others taken into custody in connection with the assassination of former Colombo District MP Bharatha Lakshman Premachandra was put off for October 11, 2013 by Colombo Additional Magistrate Priyantha Liyanage yesterday. At the outset, President's Counsel Hemantha Warnakulasuriya, senior counsel for MP Silva submitted a medical ...

  • Tamils for Obama Praises UN Human Rights Commissioner for Her Honest Account of her Trip to Sri Lanka

    General Sources - Friday 27th September, 2013

    UN High Commissioner for Human Rights, Navi Pillay visited Sri Lanka and issued an "unusually blunt" account of her findings in northeastern Sri Lanka. Tamils for Obama praise Ms. Pillay for her straight forward account and express hope that she will continue with ...

  • Canadian faces 15-year sentence in the U.S. for aiding Tamil Tigers

    CTV - Friday 27th September, 2013

    A Malaysian protester of Tamil ethnicity holds a flag of Liberation Tigers of Tamil Eelam (LTTE) during a demonstration in this 2009 file photo. (AP Photo/Lai Seng ...

  • Staggered power cuts in Colombo Fort and Pettah

    Ada Derana - Friday 27th September, 2013

    Two to three hour power cuts will be imposed on staggered basis from 8.00am tomorrow to 8.00am Monday (Sep 30) in Colombo Fort and Pettah areas, the Ceylon Electricity Board (CEB) ...

  • Sri Lanka president uses his time in U.N. spotlight to lash out

    General Sources - Friday 27th September, 2013

    Mahinda Rajapaksa, the president of Sri Lanka, delivers his speech at the U.N. General Assembly in New York. In an interview later at his hotel, he deflected criticism of his government?s rights record and said the U.N. and Western powers seemed bent on harassing Sri ...

  • Businessman shot dead on Bloemendhal Road

    Ada Derana - Friday 27th September, 2013

    A businessman was shot and killed on Bloemendhal Road in Kotahena today by unidentified gunmen who had arrived in a car, police said. The shooting was carried out at around 4.10pm today by a group of unidentified men who managed to escape in a car following the shooting, Police Spokesman SP Buddhika Siriwardena said. The victim was admitted to the Colombo National Hospital with gunshot wounds, ...

  • Kataragama Devalaya closed from tomorrow

    Ada Derana - Friday 27th September, 2013

    The Kataragama Devalaya will be closed for the public from 10.30am tomorrow (28) to 6.30pm on October 2 due to the demise of the Chief Incumbent of the Kiriwehera Temple.The Most Venerable Dr. Aluthwewa Soratha Nayaka Thero, chief incumbent of the Kataragama Kiriwehera Temple and Chancellor of the Uva Wellassa University, passed away today at the age of 70.The Thero passed away while receiving ...

  • Sri Lanka rupee weaker on importer dollar demand despite cbank direction

    Reuters - Friday 27th September, 2013

    COLOMBO, Sept 27 | Fri Sep 27, 2013 7:59am EDT COLOMBO, Sept 27 (Reuters) - The Sri Lankan rupee ended weaker on Friday on importer dollar demand, while the central bank's direction not to trade above 132.00 per dollar made dealers trade in the forward market, dealers said. The rupee spot quoted at 131.90/132.10, compared with Thursday's close of 131.90/132.00. The rupee spot ...

  • Berty Premalal Dissanayake passes away

    Ada Derana - Friday 27th September, 2013

    Former Chief Minister of the North Central Province Berty Premalal Dissanayake has passed away at the age of 59. He was receiving treatment for a lengthy illness at a private hospital in Colombo when he passed away, a relative of the veteran politician said.Dissanayake was the chief Minister of the North Central Province of Sri Lanka from June 1999 to 2012.His son, MP Duminda Dissanayake is the ...

  • Commonwealth urged to look at Sri Lanka?s rights record

    General Sources - Friday 27th September, 2013

    COLOMBO, Sri Lanka (AP) -- Two international human rights groups urged a Commonwealth advisory group to prioritize human rights in Sri Lanka, where the group is holding a heads of state meeting in November, saying the island nation has failed to properly probe alleged war-time ...

  • Election results will lead to reconciliation in Sri Lanka - Samarasinghe

    Ada Derana - Friday 27th September, 2013

    Sri Lankan High Commissioner to Australia Admiral Thisara Samarasinghe says the Tamil National ...

  • Dr. Aluthwewa Soratha Thero passes away

    Ada Derana - Friday 27th September, 2013

    Most Venerable Dr Aluthwewa Soratha Nayaka Thero, the chief incumbent of the Kataragama Kiriwehera Temple and Chancellor of the Uva Wellassa University, has passed away at the age of 70. The Thero was receiving treatment at a private hospital in Colombo when he passed away today, a spokesman said.Born on April 04, 1943, Dr. Aluthweva Soratha Thero was also the Chief Sanganayaka of Ruhuna ...

  • Sri Lanka rejects Navi Pillays call for international probe

    General Sources - Friday 27th September, 2013

    Sri Lanka has rejected United Nations Rights Chief Navi Pillay?s call for an international probe if it fails to show clear progress by next March in probing alleged war crimes during the three-decade long conflict with ...

  • Source: http://www.srilankannews.net/index.php/sid/217382911/scat/119937e494dd663e

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    Friday, September 27, 2013

    Mitchell 2008 Dodge Durango Used SUV near Sioux Falls, SD Brookings, SD Vern Eide Ford Lincoln for $9,945

    • Bright White Clearcoat
    • Dk/Lt Slate Gray w/Cloth Bucket Seats
    • F93035A
    • 3.7L V6
    • 1D8HD38K38F132985
    • Automatic 4-Speed
    • 75,022 mi.
    • RWD SUV (4 Door)

    ?

    • Convenience

      • Air conditioning
      • Center Console - Full with covered storage
      • Cruise control
      • Power steering
      • Tilt steering wheel
      • Clock - In-radio display
      • Tachometer
      • Remote power door locks
      • Power heated mirrors
      • Power windows with 2 one-touch
      • Rear defogger
    • Exterior

      • Chrome grill
      • Roof rack - Rails only
      • Intermittent window wipers
      • Privacy/tinted glass
      • Rear wiper
    • Interior

      • Split-bench rear seats
      • Front seat type - Bucket
    • Safety

      • 4-wheel ABS brakes
      • Head airbags - Curtain 1st and 2nd row
      • Passenger Airbag
      • Stability control - With anti-roll control
      • Traction control - ABS and driveline
    • Technical

    • Not all issues are reported to CARFAX. The number of owners is estimated. See the full CARFAX Report for additional information and glossary of terms.

    Payment $174.37

    $9,945

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    EPA mileage estimates are for newly manufactured vehicles only. Your actual mileage will vary depending on how you drive and maintain your vehicle.

    Before purchasing this vehicle, it is your responsibility to address any and all differences between information on this website and the actual vehicle specifications and/or any warranties offered prior to the sale of this vehicle. Vehicle data on this website is compiled from publicly available sources believed by the publisher to be reliable. Vehicle data is subject to change without notice. The publisher assumes no responsibility for errors and/or omissions in this data the compilation of this data and makes no representations express or implied to any actual or prospective purchaser of the vehicle as to the condition of the vehicle, vehicle specifications, ownership, vehicle history, equipment/accessories, price or warranties.

    Source: http://www.verneideford.com/Used-2008-Dodge-Durango-Mitchell/vd/16515579

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    In prostate cancer prognosis, telomere length may matter

    In prostate cancer prognosis, telomere length may matter [ Back to EurekAlert! ] Public release date: 26-Sep-2013
    [ | E-mail | Share Share ]

    Contact: Vanessa Wasta
    wasta@jhmi.edu
    410-614-2916
    Johns Hopkins Medicine

    Like the plastic caps at the end of shoelaces, telomeres protect in their case the interior-gene containing parts of chromosomes that carry a cell's instructional material. Cancer cells are known to have short telomeres, but just how short they are from cancer cell to cancer cell may be a determining factor in a prostate cancer patient's prognosis, according to a study led by Johns Hopkins scientists.

    "Doctors are looking for new ways to accurately predict prostate cancer patients' prognoses, because the current methods that use disease stage, Gleason score, and PSA are not perfect," says Alan Meeker, Ph.D., assistant professor of pathology at The Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "Telomere shortening is common in cancer, but the degree of shortening varies from one cancer cell to another within each patient, and this variability may give us a better idea of how prostate cancers behave."

    In the study, described in the October issue of Cancer Discovery, the scientists studied tissue samples from 596 men surgically treated for prostate cancer thought to be confined to the prostate and who were participants in a long-term follow-up study on men's health. Then, they used images of prostate cancer cells and nearby cells called stroma, which include smooth muscle and fibroblast cells, taken from surgery-tissue samples of each patient.

    Meeker and his team used a technique they developed called telomere-specific fluorescent in situ hybridization (TELI-FISH) to measure telomere length in cancer and stromal cells. The technique uses fluorescent-labeled probes specific for particular locations in DNA, and is commonly used to detect or confirm gene or chromosome abnormalities. In the new study, a fluorescent probe specific for telomere regions was added to the cells, enabling the scientists to identify these specific chromosomal locations under a microscope and measure the level of fluorescence that corresponds to telomere length.

    After determining telomere length for more than 40,000 cells among the samples, disease-pattern experts at Johns Hopkins then correlated telomere length measurements in the cancer and stromal cells with each patient's survival.

    "Men who had a combination of more variable telomere length among cancer cells and shorter telomere length in stromal cells were more likely to develop metastatic disease and die sooner from their prostate cancer than other men," says Elizabeth Platz, Sc.D., M.P.H., professor of epidemiology at The Johns Hopkins Bloomberg School of Public Health and the Martin D. Abeloff Scholar in Cancer Prevention at the Johns Hopkins Kimmel Cancer Center.

    In the group of 98 men with more variable telomere length in cancer cells and shorter telomeres in stromal cells, 20 died of their prostate cancer an average of 8.4 years after diagnosis. Accounting for standard prognostic factors, these men were 14 times more likely to die of their prostate cancer compared with another group of 98 men whose telomeres had less variable length among cancer cells and were longer in stromal cells. In this group, only one man died, and that was after 16.5 years.

    "Our studies strongly suggest that the combination of telomere length in stromal cells and its variability among prostate cancer cells could be a marker for prostate cancer prognosis," says Platz.

    Meeker and Platz are continuing to study additional groups of patients and are now using an automated fluorescence microscope and computer software to speed the collection of tissue images and extract telomere data.

    ###

    Funding for the study was provided by the Department of Defense, the National Institutes of Health's National Cancer Institute (CA58236, CA55075, CA72036, CA133891, CA141298) and National Heart, Lung, and Blood Institute (HL35464), the Seraph Foundation, and the Prostate Cancer Foundation.

    Tissue samples used for the study were taken from men enrolled in Harvard's Health Professionals Follow-Up Study.

    Scientists contributing to the research include Christopher M. Heaphy, Ghil Suk Yoon, Sarah B. Peskoe, Corinne E. Joshu, Thomas K. Lee, Jessica L. Hicks, and Angelo M. De Marzo at Johns Hopkins; and Edward Giovannucci, Stacey A. Kenfield, Lorelei A. Mucci, and Meir J. Stampfer at Harvard School of Public Health.

    JOHNS HOPKINS MEDICINE

    Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is a $6.7 billion integrated global health enterprise and one of the leading health care systems in the United States. JHM unites physicians and scientists of the Johns Hopkins University School of Medicine with the organizations, health professionals and facilities of The Johns Hopkins Hospital and Health System. JHM's mission is to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care. Diverse and inclusive, JHM educates medical students, scientists, health care professionals and the public; conducts biomedical research; and provides patient-centered medicine to prevent, diagnose and treat human illness. JHM operates six academic and community hospitals, four suburban health care and surgery centers, more than 38 primary health care outpatient sites and other businesses that care for national and international patients and activities. The Johns Hopkins Hospital, opened in 1889, was ranked number one in the nation for 21 years by U.S. News & World Report.

    Johns Hopkins Kimmel Cancer Center
    Office of Public Affairs
    Media Contacts:

    Vanessa Wasta
    410-614-2916
    wasta@jhmi.edu

    Amy Mone
    410-614-2915
    amone@jhmi.edu


    [ Back to EurekAlert! ] [ | E-mail | Share Share ]

    ?


    AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


    In prostate cancer prognosis, telomere length may matter [ Back to EurekAlert! ] Public release date: 26-Sep-2013
    [ | E-mail | Share Share ]

    Contact: Vanessa Wasta
    wasta@jhmi.edu
    410-614-2916
    Johns Hopkins Medicine

    Like the plastic caps at the end of shoelaces, telomeres protect in their case the interior-gene containing parts of chromosomes that carry a cell's instructional material. Cancer cells are known to have short telomeres, but just how short they are from cancer cell to cancer cell may be a determining factor in a prostate cancer patient's prognosis, according to a study led by Johns Hopkins scientists.

    "Doctors are looking for new ways to accurately predict prostate cancer patients' prognoses, because the current methods that use disease stage, Gleason score, and PSA are not perfect," says Alan Meeker, Ph.D., assistant professor of pathology at The Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "Telomere shortening is common in cancer, but the degree of shortening varies from one cancer cell to another within each patient, and this variability may give us a better idea of how prostate cancers behave."

    In the study, described in the October issue of Cancer Discovery, the scientists studied tissue samples from 596 men surgically treated for prostate cancer thought to be confined to the prostate and who were participants in a long-term follow-up study on men's health. Then, they used images of prostate cancer cells and nearby cells called stroma, which include smooth muscle and fibroblast cells, taken from surgery-tissue samples of each patient.

    Meeker and his team used a technique they developed called telomere-specific fluorescent in situ hybridization (TELI-FISH) to measure telomere length in cancer and stromal cells. The technique uses fluorescent-labeled probes specific for particular locations in DNA, and is commonly used to detect or confirm gene or chromosome abnormalities. In the new study, a fluorescent probe specific for telomere regions was added to the cells, enabling the scientists to identify these specific chromosomal locations under a microscope and measure the level of fluorescence that corresponds to telomere length.

    After determining telomere length for more than 40,000 cells among the samples, disease-pattern experts at Johns Hopkins then correlated telomere length measurements in the cancer and stromal cells with each patient's survival.

    "Men who had a combination of more variable telomere length among cancer cells and shorter telomere length in stromal cells were more likely to develop metastatic disease and die sooner from their prostate cancer than other men," says Elizabeth Platz, Sc.D., M.P.H., professor of epidemiology at The Johns Hopkins Bloomberg School of Public Health and the Martin D. Abeloff Scholar in Cancer Prevention at the Johns Hopkins Kimmel Cancer Center.

    In the group of 98 men with more variable telomere length in cancer cells and shorter telomeres in stromal cells, 20 died of their prostate cancer an average of 8.4 years after diagnosis. Accounting for standard prognostic factors, these men were 14 times more likely to die of their prostate cancer compared with another group of 98 men whose telomeres had less variable length among cancer cells and were longer in stromal cells. In this group, only one man died, and that was after 16.5 years.

    "Our studies strongly suggest that the combination of telomere length in stromal cells and its variability among prostate cancer cells could be a marker for prostate cancer prognosis," says Platz.

    Meeker and Platz are continuing to study additional groups of patients and are now using an automated fluorescence microscope and computer software to speed the collection of tissue images and extract telomere data.

    ###

    Funding for the study was provided by the Department of Defense, the National Institutes of Health's National Cancer Institute (CA58236, CA55075, CA72036, CA133891, CA141298) and National Heart, Lung, and Blood Institute (HL35464), the Seraph Foundation, and the Prostate Cancer Foundation.

    Tissue samples used for the study were taken from men enrolled in Harvard's Health Professionals Follow-Up Study.

    Scientists contributing to the research include Christopher M. Heaphy, Ghil Suk Yoon, Sarah B. Peskoe, Corinne E. Joshu, Thomas K. Lee, Jessica L. Hicks, and Angelo M. De Marzo at Johns Hopkins; and Edward Giovannucci, Stacey A. Kenfield, Lorelei A. Mucci, and Meir J. Stampfer at Harvard School of Public Health.

    JOHNS HOPKINS MEDICINE

    Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is a $6.7 billion integrated global health enterprise and one of the leading health care systems in the United States. JHM unites physicians and scientists of the Johns Hopkins University School of Medicine with the organizations, health professionals and facilities of The Johns Hopkins Hospital and Health System. JHM's mission is to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care. Diverse and inclusive, JHM educates medical students, scientists, health care professionals and the public; conducts biomedical research; and provides patient-centered medicine to prevent, diagnose and treat human illness. JHM operates six academic and community hospitals, four suburban health care and surgery centers, more than 38 primary health care outpatient sites and other businesses that care for national and international patients and activities. The Johns Hopkins Hospital, opened in 1889, was ranked number one in the nation for 21 years by U.S. News & World Report.

    Johns Hopkins Kimmel Cancer Center
    Office of Public Affairs
    Media Contacts:

    Vanessa Wasta
    410-614-2916
    wasta@jhmi.edu

    Amy Mone
    410-614-2915
    amone@jhmi.edu


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    Source: http://www.eurekalert.org/pub_releases/2013-09/jhm-ipc092613.php

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